解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Gangliosides have been extensively described to be involved in the proliferation and differentiation of various cell types, such including hematopoietic cells. Our previous studies on murine models of stroma-mediated myelopoiesis have shown that gangliosides are required for optimal capacity of stromal cells to suppor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.08.032
更新日期:2011-12-01 00:00:00
abstract::Inflammation may play a major role in the pathogenesis of preeclampsia (PE). In this meta-analysis, we determined whether maternal polymorphisms and serum concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) were associated with PE. All studies investigating the assoc...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2011.09.021
更新日期:2011-12-01 00:00:00
abstract::Therapeutic plasmapheresis is a recognized medical procedure in which various techniques are used to separate and remove undesirable or excessively elevated plasma elements from blood. The main purpose of the procedure is to remove the substances responsible for the disease (autoantibodies, circulating immune complexe...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2011.08.038
更新日期:2011-12-01 00:00:00
abstract::Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has proven effective in modifying the course of SSc, a reflection of its complex pathogenesis. T cell-derived cytokines have been implicated ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2011.08.030
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Dysregulated production of TNF has been implicated in the pathogenesis and severity of inflammatory rheumatic diseases, many of which show age-related increased incidence. Ageing is also associated with changes in the immune system including higher systemic levels of pro-inflammatory cytokines. Methylation o...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.09.009
更新日期:2011-12-01 00:00:00
abstract::Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.06.003
更新日期:2011-11-01 00:00:00
abstract::Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.07.002
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.06.023
更新日期:2011-11-01 00:00:00
abstract::IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2011.07.006
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-γ. We...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.05.011
更新日期:2011-09-01 00:00:00
abstract:UNLABELLED:Burn is associated with profound inflammation and activation of the innate immune system in multiple organ beds, including the lung. Similarly, toll-like receptors (TLR) are associated with innate immune activation. Nonetheless, it is unclear what impact burn has on TLR-induced inflammatory responses in the ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.05.004
更新日期:2011-09-01 00:00:00
abstract::Exercise training is known to induce a molecular adaptation process involving inflammatory responses. However any time-of-day effect of exercise on inflammatory responses remains unknown. The aim of the present study was to investigate whether acute bouts of intense exercise performed at different times of the day wou...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.05.005
更新日期:2011-08-01 00:00:00
abstract::A well-known association between vitamin D(3) and infection with Mycobacterium tuberculosis has previously been reported, but little is known regarding the underlying mechanisms. We have investigated how 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] affects the proinflammatory cytokine production induced by M. tubercul...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.04.016
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:The effects of LDL-apheresis (LDLa) with dextran sulphate on plasma cytokines in 6 homozygous familial hypercholesterolemic (HozFH) patients, were evaluated. METHODS:Plasma IL-1α; IL-1ra; IL-4; IL-6; IL-10; IL-12(p40); IL-12(p70); TNF-α, sTNF-R, VEGF, VEGF-R1, E-Selectin (ESEL), and P-Selectin (PSEL) concent...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.04.003
更新日期:2011-08-01 00:00:00
abstract::Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.03.006
更新日期:2011-07-01 00:00:00
abstract::Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.03.002
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.03.020
更新日期:2011-07-01 00:00:00
abstract:AIM:High mobility group box 1 protein (HMGB1) has been identified as a late proinflammatory cytokine and plays a key role in immune regulation. However, it is not yet clear whether HMGB1 can induce the activation and differentiation of dendritic cell (DC) subsets and subsequently modulate immune function of T cells. Th...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.01.008
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:Mycoplasma pneumoniae (M. pneumoniae) is a common causative agent of pneumonia in children. The aim of this study is to determine whether there is any difference in selected cytokine or chemokines response in asthmatic children compared to non-asthmatic children during acute M. pneumoniae pneumonia. METHODS:Se...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.02.008
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.01.016
更新日期:2011-05-01 00:00:00
abstract::Granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) are more frequently used as the cellular source in allogeneic hematopoietic stem cell transplantation (HSCT) than bone marrow stem cells (BMSCs) because they promote more rapid engraftment and immune reconstitution. However, th...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.12.020
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.12.007
更新日期:2011-03-01 00:00:00
abstract::CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.11.017
更新日期:2011-03-01 00:00:00
abstract::The aim of the study was to test the hypothesis that B-cell repopulation following rituximab (anti-CD20) therapy is orchestrated by chemokines and non-chemokine cytokines. Twenty-five children with opsoclonus-myoclonus syndrome (OMS) received rituximab with or without conventional agents. A comprehensive panel of 40 c...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.12.004
更新日期:2011-03-01 00:00:00
abstract::iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The capacity of iNKT cells to produce regulatory cytokines first provided an indication of their regulatory potential. Later on, in experimental models as well as in patients afflicted with an auto-immune disease, such as Type 1 diab...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.11.001
更新日期:2011-03-01 00:00:00
abstract::The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of h...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.10.007
更新日期:2011-02-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) demonstrating pro-angiogenic activity promote new blood vessel formation in psoriatic lesions. The aim of this study was to evaluate the serum concentrations of VEGF, its soluble receptors (sVEGF R1 and R2) and VEGF content in scales of patients with psoriasis. To analyze poss...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.09.012
更新日期:2010-12-01 00:00:00
abstract::This study was designed to compare the effect of Aspirin (AS) and Nimesulide (NM) on renal failure and vascular disorder in streptozotocin (STZ)-induced diabetic rats. Rats were divided into four groups; control, diabetic rats, diabetic rats plus AS and diabetic rats plus NM, which are COX inhibitors. The renal and ao...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.07.004
更新日期:2010-12-01 00:00:00
abstract::Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.08.001
更新日期:2010-12-01 00:00:00
abstract::Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against var...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.06.011
更新日期:2010-10-01 00:00:00
abstract::Over the last two decades, a lot of research work has been focused on the interferon (IFN)-regulated JAK-STAT pathway and understanding the mechanisms governing the transcription of interferon stimulated genes (ISGs). Evidence suggests that the JAK-STAT pathway alone does not account in its entirety for mediating cell...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.03.019
更新日期:2010-10-01 00:00:00
abstract::Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.06.009
更新日期:2010-09-01 00:00:00
abstract::Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.04.016
更新日期:2010-09-01 00:00:00
abstract::Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.05.002
更新日期:2010-08-01 00:00:00
abstract::Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.04.004
更新日期:2010-07-01 00:00:00
abstract::Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the eff...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.03.015
更新日期:2010-07-01 00:00:00
abstract::Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.03.014
更新日期:2010-07-01 00:00:00
abstract::We present evidence that cervical cancer cells express a functional IL-2 receptor (IL-2R). In fact, by RT-PCR we obtained that the IL-2R is present in CALO, and INBL cells, and that it consisted of the alphaIL-2R, betaIL-2R, and gammaIL-2R chains. We also found that IL-2 is a growth factor for these cell lines, and un...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.013
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.002
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Cardiac surgery is associated with inflammatory responses that are known to affect its outcome. The present study was designed to define whether post-operative release of interleukin (IL)-6, 8 and tumor necrosis factor-alpha (TNF-alpha) is related to the presence of a certain allele in functional polymorphis...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.007
更新日期:2010-06-01 00:00:00